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KMID : 1130620190150040517
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Journal of Clinical Neurology
2019 Volume.15 No. 4 p.517 ~ p.526
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The Influence of Body Mass Index at Diagnosis on Cognitive Decline in Parkinson's Disease
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Yoo Han-Soo
Chung Seok-Jong
Lee Phil-Hyu
Sohn Young-H.
Kang Suk-Yun
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Abstract
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Background and Purpose: Associations between alterations in body mass index (BMI) and cognitive function have been reported in Parkinson's disease (PD). We investigated whether the BMI at a PD diagnosis is associated with cognitive decline and the future development of dementia.
Methods: We recruited 70 patients with de novo PD who underwent neuropsychological testing every 3 years and were followed up for more than 6 years. We classified patients into the following three groups based on their BMI at the diagnosis: under-/normal weight (n=21), overweight (n=22), and obese (n=27). We evaluated differences in the rate of cognitive decline over time among the groups using linear mixed models and the conversion rate to dementia using survival analysis.
Results: The obese patients with PD showed a slower deterioration of global cognitive function as well as language and memory functions than did the under-/normal-weight group during the 6-year follow-up. The three BMI groups showed different rates of conversion to dementia (log-rank test: p=0.026). The combined overweight and obese group showed a lower risk of developing dementia compared with the under-/normal-weight group (hazard ratio= 0.36, 95% CI=0.12?0.82, p=0.046).
Conclusions: We have demonstrated that a higher-than-normal BMI at the time of a PD diagnosis has a protective effect against the deterioration of cognitive function and the conversion to dementia.
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KEYWORD
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body mass index, cognitive decline, neuropsychological test, Parkinson disease, Parkinson's disease dementia
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